The Bacterial Cell Surface

It is a common statement that because of its simplicity the bacterial cell makes an ideal model for the study of a wide variety of biological systems and phenomena. While no-one would dispute that much of our under­ standing of biological function derives from the study of the humble bacterium, the concept of a simple life-form would be hotly disputed by any scientist engaged in the determination of the relationship between structure and function within the bacterial cell. Bacteria are particularly amenable to intensive study; their physiology can be probed with powerful biochemical, genetical and immunological techniques. Each piece of information obtained inevitably raises as many questions as answers, and can lead to a highly confused picture being presented to the lay reader. Nowhere is this more evident than in the study of the surface layers of the bacterial cell. Examination of the early electron micrographs suggested that the bacterial cytoplasm was surrounded by some sort of semi-rigid layer, possessing sufficient intrinsic strength to protect the organism from osmotic lysis. The belief that the surface layers were rather passive led to their neglect, while researchers concentrated on the superficially more exciting cytoplasmic components. Over the last twenty years our view of the bacterial envelope has undergone extensive revision, revealing a structure of enormous complexity. Content: Front Matter....Pages i-vii The Peptidoglycan Layer....Pages 1-28 Walls of Gram-Positive Bacteria....Pages 29-56 The Envelope of Gram-Negative Bacteria....Pages 57-118 Surface Appendages: Flagella and Fimbriae....Pages 119-146 The Cell Envelope in Bacterial Disease....Pages 147-193 The Bacterial Cell Surface in Relation to the Environment....Pages 194-219 Back Matter....Pages 220-226