The Delta Receptor

The Delta Receptor spans current research in delta receptor biology, pharmacology, physiology, and chemistry to identify, advance, and inspire the development of novel drug candidates. It demonstrates the potential significance and impact of the delta receptor in the therapy and treatment of medical conditions such as pain, gastrointestinal disorders, bladder dysfunction, and depression, as well as heart attack prevention. This reference examines the pathophysiological functions and mechanisms of receptor-selective drugs. Documenting key advances in the field, The Delta Receptor represents the most comprehensive and up-to-date studies on receptor applications currently available. 1. History Of Delta Receptors / Kwen-jen Chang -- 2. Cloning Of Delta Opioid Receptors / Arnaud Lacoste And Christopher J. Evans -- 3. Cloning And Expression Of The Human Delta Opioid Receptor / Richard J. Knapp, Ewa Malatynska, Eva V. Varga, William R. Roeske And Henry I. Yamamura -- 4. In Vitro And In Vivo Mutagenesis: Insights Into Delta Receptor Structure And Function / F. M. Decaillot And Brigitte L. Kieffer -- 5. Delta Opioid Receptor Signaling And Trafficking / P. Y. Law -- 6. Delta Opioid Receptors And G Proteins / Mary J. Clark And John R. Traynor -- 7. Transcriptional Regulation Of Delta Opioid Receptor Gene / Ping Sun And Horace Loh -- 8. Benzhydrylpiperazines As Nonpeptidic Delta Opioid Receptor Ligands / Michael J. Bishop And Robert W. Mcnutt -- 9. Delta-selective Ligands Related To Naltrindole / D. J. Daniels And P. S. Portoghese -- 10. Endogenous Peptides For Delta Opioid Receptors And Analogues / Victor J. Hruby And Henry I. Mosberg -- 11. Deltorphins / Lucia Negri And Elisa Giannini -- 12. Opioid Peptide-derived Delta Antagonists, Inverse Agonists, And Mixed Mu Agonists/delta Antagonists / Peter W. Schiller -- 13. Inverse Agonism At The Delta Opioid Receptors / Eva V. Varga, Keiko Hosohata, Yoshiaki Hosohata, Jennifer Tsang, Thomas Burkey, Josue Alfaro-lopez, Xuejun Tang, Victor J. Hruby, William R. Roeske And Henry I. Yamamura -- 14. Mixed Opioid Receptor Agonists As A New Class Of Agents For The Treatment Of Moderate To Severe Pain / Peter J. Gengo And Kwen-jen Chang -- 15. Biphalin: A Multireceptor Opioid Ligand / Andrzej W. Lipkowski, Daniel B. Carr, Iwona Bonney And Aleksandra Misicka -- 16. Binding And Activity Of Opioid Ligands At The Cloned Human Delta, Mu, And Kappa Receptors / Kemal Payza -- 17. Inhibitors Of Enkephalin-inactivating Enzymes And Delta Opioid Responses / Bernard P. Roques And Florence Noble -- 18. The Delta Opioid Receptor Subtypes And Pain Modulation / Michael H. Ossipov, Josephine Lai, Todd W. Vanderah And Frank Porreca -- 19. Delta Opioid Receptor-mediated Antinociception Analgesia / Minoru Narita And Tsutomu Suzuki -- 20. Antidepressant-like Effects Of Delta Opioid Receptor Agonists / Emily M. Jutkiewicz And James H. Woods -- 21. Mu-delta Interactions In Vitro And In Vivo / Richard B. Rothman And Heng Xu -- 22. Delta Opioids And Immune Function / Richard J. Weber And Ricardo Gomez-flores -- 23. Delta Opioids And Substance Abuse / S. Stevens Negus -- 24. Delta Opioid Receptors In The Gastrointestinal Tract / Dewayne Townsend Iv And David R. Brown -- 25. Cardioprotection And Delta Opioid Receptors / Garrett J. Gross, Ryan M. Fryer, Hemal H. Patel And Jo El J. Schultz -- 26. The Delta Opioid Receptor And Brain Pain Modulating Circuits / Mary M. Heinricher And Howard L. Fields. Edited By Kwen-jen Chang, Frank Porreca, James Woods. Includes Bibliographical References And Index. The discovery of two endogenous opiate- or morphinelike peptides, Leu-enkephalin and Met-enkephalin, by Hughes and colleagues in 1975 [1] led to the explosive advances in our understanding of the functions of opioid receptors and the actions of opiates and opioids in the last two decades.