Viral Hepatitis

There has been an explosion of both the incidence and medical knowledge of viral hepatitis over the last two decades. Not only is the incidence of infection and disease increasing, but new hepatitis viruses have been discovered, as well as the launch of new pharmaceutical products.Previously published by Churchill Livingstone, __Viral Hepatitis__ by Zuckerman & Thomas was the first comprehensive book on hepatitis and is recognized as **the** standard reference text in this field. The new third edition, now published by Blackwell Publishing, addresses the recent advances in diagnosis and treatment with entirely revised and current topics. It covers the entire spectrum of viral hepatitis and has something of interest for every specialist. __Viral Hepatitis__ presents the latest thinking from the leading international researchers and clinicians working in this field and the Editors are joined by a North American co-Editor for this edition - Professor Stanley Lemon of the University of Texas, Galveston, TX, USA. This book offers an ideal reference for all healthcare professionals involved in the research and patient care of this disease.Content: Chapter 1 Liver Stem Cells in Persistent Viral Infection, Liver Regeneration and Cancer (pages 1–14): Stuart Forbes and Malcolm AlisonChapter 2 Hepatic Immunology (pages 15–29): Cliona O'Farrelly, Robert H Pierce and Nicholas CrispeChapter 3 Clinical Features of Hepatitis (pages 31–49): Arie Regev and Eugene R SchiffChapter 4 Diagnostic Approach to Viral Hepatitis (pages 50–64): Julie C Servoss, Lawrence S Friedman and Jules L DienstagChapter 5 Evolution of Hepatitis Viruses (pages 65–75): Peter SimmondsChapter 6 Structure and Molecular Virology (pages 77–91): Stanley M Lemon and Annette MartinChapter 7 Epidemiology (pages 92–108): Mike G Catton and Stephen A LocarniniChapter 8 Natural History and Experimental Models (pages 109–125): Robert H Purcell and Suzanne U EmersonChapter 9 Prevention (pages 126–145): Beth P BellChapter 10 Structure and Molecular Virology (pages 147–180): Michael Kann and Wolfram H GerlichChapter 11 Epidemiology (pages 181–192): Daniel LavanchyChapter 12 Avihepadnaviridae (pages 193–209): Allison R Jilbert and Stephen A LocarniniChapter 13 Woodchuck Hepatitis Virus (pages 210–224): Michael Roggendorf and Michael LuChapter 14 Hepatitis B Surface Antigen (HBsAg) Variants (pages 225–241): William F Carman, Mohammad Jazayeri, Ashraf Basuni, Howard C Thomas and Peter KarayiannisChapter 15 Molecular Variations in the Core Promoter, Precore and Core Regions of Hepatitis B Virus, and their Clinical Significance (pages 242–262): Peter Karayiannis, William F Carman and Howard C ThomasChapter 16 Natural History of Chronic Hepatitis B and Hepatocellular Carcinoma (pages 263–268): Massimo Colombo and Pietro LamperticoChapter 17 Hepatocellular Carcinoma: Molecular Aspects in Hepatitis B (pages 269–294): Marie Annick Buendia, Patricia Paterlini?Brechot, Pierre Tiollais and Christian BrechotChapter 18 Murine Models and Hepatitis B Virus Infection (pages 295–307): David R MilichChapter 19 Pathogenesis of Chronic Hepatitis B (pages 308–322): Mark R Thursz and Howard C ThomasChapter 20 Treatment of Chronic Hepatitis B (pages 323–336): Patrick Marcellin, Tarik Asselah and Nathalie BoyerChapter 21 Management of Drug?Resistant Mutants (pages 337–344): Yun?Fan LiawChapter 22 Liver Transplantation in the Management of Chronic Viral Hepatitis (pages 345–369): Marina Berenguer and Teresa L WrightChapter 23 Prevention (pages 370–377): Jane N ZuckermanChapter 24 Structure and Molecular Virology (pages 379–406): Michael J McGarvey and Michael HoughtonChapter 25 Epidemiology (pages 407–425): Josep Quer and Juan I Esteban MurChapter 26 The Immune Response to Hepatitis C Virus in Acute and Chronic Infection (pages 426–438): Khadija Iken and Margaret J KozielChapter 27 Natural History and Experimental Models (pages 439–467): Patrizia Farci, Jens Bukh and Robert H PurcellChapter 28 Autoimmune Disorders (pages 468–481): Elmar Jaeckel and Michael P MannsChapter 29 Central Nervous System Complications (pages 482–495): Daniel M Forton, Simon D Taylor?Robinson, I Jane Cox and Howard C ThomasChapter 30 In Vitro Replication Models (pages 496–510): Ralf Bartenschlager and Sandra SparacioChapter 31 Progression of Fibrosis (pages 511–519): Thierry Poynard, Vlad Ratziu, Yves Benhamou, Dominique Thabut and Joseph MoussalliChapter 32 The Natural History of Hepatitis C and Hepatocellular Carcinoma (pages 520–525): Edward TaborChapter 33 Treatment of Chronic Hepatitis C (pages 526–539): Jenny Heathcote and Janice MainChapter 34 New Drugs for the Management of Hepatitis C (pages 540–552): John G McHutchison, Jennifer M King and Amany ZekryChapter 35 Prevention (pages 553–567): Sergio Abrignani, Grazia Galli and Michael HoughtonChapter 36 Structure and Molecular Virology (pages 569–582): Michael MC LaiChapter 37 Epidemiology and Natural History (pages 583–592): Floriano Rosina and Mario RizzettoChapter 38 Treatment (pages 593–600): Grazia Anna Niro, Floriano Rosina and Mario RizzettoChapter 39 Structure and Molecular Virology (pages 601–610): David A Anderson and R Holland ChengChapter 40 Hepatitis E as a Zoonotic Disease (pages 611–623): Xiang?Jin MengChapter 41 Epidemiology, Clinical and Pathologic Features, Diagnosis, and Experimental Models (pages 624–634): Kris Krawczynski, Rakesh Aggarwal and Saleem KamiliChapter 42 Prevention (pages 635–648): Robert H Purcell and Suzanne U EmersonChapter 43 Aetiology of Fulminant Hepatitis (pages 649–665): Kittichai Promrat and Jack R WandsChapter 44 Treatment of Fulminant Hepatitis (pages 666–681): Kinan Rifai, Hans L Tillmann and Michael P MannsChapter 45 Hepatitis and Haemophilia (pages 682–692): Christine A LeeChapter 46 Occupational Aspects of Hepatitis (pages 693–713): William L Irving and Kit HarlingChapter 47 Neonatal and Paediatric Infection (pages 714–739): Deirdre Kelly and Elizabeth BoxallChapter 48 Management of Hepatocellular Cancer (pages 740–754): Helen L Reeves and Jordi BruixChapter 49 Application of Molecular Biology to the Diagnosis of Viral Hepatitis (pages 755–768): Jean?Michel PawlotskyChapter 50 Hepatitis in HIV?Infected Persons (pages 769–779): Janice Main and Brendan McCarronChapter 51 Treatment of Extrahepatic Diseases Caused by Hepatitis B and Hepatitis C Viruses (pages 780–793): Philippe Merle and Christian TrepoChapter 52 The Histologist's Role in the Diagnosis and Management of Chronic Hepatitis B and C (pages 794–803): Robert Goldin and Geoffrey M DusheikoChapter 53 Disinfection and Sterilization (pages 804–814): Martin S Favero and Walter W BondChapter 54 Mechanisms of Interferon Resistance (pages 815–823): Darius Moradpour, Markus H Heim and Hubert E BlumChapter 55 New In Vitro Testing Systems for Hepatitis B and C Viruses (pages 824–840): David Durantel, Olivier Hantz, Christian Trepo and Fabien ZoulimChapter 56 New Vaccine Technologies and the Control of Viral Hepatitis (pages 841–850): Colin R HowardChapter 57 Safety of Hepatitis B Vaccines (pages 851–853): Arie J ZuckermanChapter 58 Before and Since the Discovery of Australia Antigen: A Chronological Review of Viral Hepatitis (pages 854–863): Philip P Mortimer and Arie J Zuckerman There Has Been An Explosion Of Both The Incidence And Medical Knowledge Of Viral Hepatitis Over The Last Two Decades. Not Only Is The Incidence Of Infection And Disease Increasing, But New Hepatitis Viruses Have Been Discovered, As Well As The Launch Of New Pharmaceutical Products. Previously Published By Churchill Livingstone, Viral Hepatitis By Zuckerman & Thomas Was The First Comprehensive Book On Hepatitis And Is Recognized As The Standard Reference Text In This Field. The New Third Edition, Now Published By Blackwell Publishing, Addresses The Recent Advances In Diagnosis And Treatment With Entirely Revised And Current Topics. It Covers The Entire Spectrum Of Viral Hepatitis And Has Something Of Interest For Every Specialist. This Book Offers An Ideal Reference For All Healthcare Professionals Involved In The Research And Patient Care Of This Disease. Liver Stem Cells / Stuart Forbes, Malcolm Alison -- Hepatic Immunology / Cliona O'farrelly, Robert H. Pierce, I. Nicholas Crispe -- Clinical Features Of Viral Hepatitis / Arie Regev, Eugene R. Schiff -- Diagnostic Approach To Viral Hepatitis / Julie C. Servoss, Lawrence S. Friedman, Jules L. Dienstag -- Evolution Of Hepatitis Viruses / Peter Simmonds -- Structure And Molecular Virology / Stanley M. Lemon, Annette Martin -- Epidemiology / G. Catton, S.a. Locarnini -- Natural History And Experimental Models / Robert H. Purcell, Suzanne U. Emerson -- Prevention / Beth P. Bell -- Structure And Molecular Virology / M. Kann, W. Gerlich. Epidemiology Of Hepatitis B / D. Lavanchy -- Avihepadnaviridae / A.r. Jilbert, S.a. Locarnini -- Woodchuck Hepatitis Virus / M. Roggendorf, M. Lu -- Hepatitis B Surface Antigen (hbsag) Variants / William F. Carman ... [et Al.] -- Molecular Variation In The Core Promoter, Precore And Core Regions Of Hepatitis B Virus, And Their Clinical Significance / P. Karayiannis, W.f. Carman, H.c. Thomas -- Natural History Of Chronic Hepatitis B And Hepatocellular Carcinoma / M. Colombo, P. Lampertico -- Hepatocellular Carcinoma : Molecular Aspects In Hepatitis B / M.a. Buendia -- Murine Models Of Hepatitis B Virus Infection / David R. Milich. Pathogenesis Of Chronic Hepatitis B / M.r. Thursz, H.c. Thomas -- Treatment / Patrick Marcellin, Tarik Asselah, Nathalie Boyer -- Management Of Drug Resistant Mutants / Yun-fan Liaw -- Liver Transplantation In The Management Of Chronic Viral Hepatitis / Marina Berenguer, Teresa L. Wright -- Prevention / Jane N. Zuckerman -- Structure And Molecular Virology / Michael J. Mcgarvey, Michael Houghton -- Epidemiology / J. Quer, J.i. Esteban -- The Immune Response To Hcv In Acute And Chronic Infection / Khadija Iken, Margaret James Koziel -- Natural History In Experimental Models / Patrizia Farci, Jens Bukh, Robert Purcell. Autoimmune Disorders / Elmar Jaeckel, Michael P. Manns -- Central Nervous System Complications / Daniel M. Forton ... [et Al.] -- In Vitro Replication Models / Ralph Bartenschlager, Sandra Sparacio -- Progression Of Hepatitis C : Hepatic Fibrosis / Thierry Poynard ... [et Al.] -- Progression Of Hepatitis C : Hepatocellular Carcinoma / Edward Tabor -- Treatment / Jenny Heathcote, Janice Main -- New Drugs / John G. Mchutchison, Jennifer M. King, Amany Zekry -- Prevention / Sergio Abrignani, Grazia Galli, Michael Houghton -- Structure And Molecular Virology / Michael M.c. Lai -- Epidemiology And Natural History / F. Rosina, M. Rizzetto. Treatment / Maria Grazia Niro, F. Rosina, M. Rizzetto -- Structure And Molecular Virology / D.a. Anderson, R.h. Cheng -- Zoonotic Aspects / X.j. Meng -- Epidemiology, Clinical And Pathologic Features, Diagnosis, And Experimental Models / K. Krawczynski, R. Aggarwal, S. Kamili -- Prevention / Robert H. Purcell, Suzanne U. Emerson -- Aetiology Of Fulminant Hepatitis / Kittichai Promrat, Jack R. Wands -- Treatment Of Fulminant Hepatitis / Kinan Rifai, Hans L. Tillmann, Michael P. Manns -- Hepatitis And Haemophilia / Christine A. Lee -- Occupational Aspects Of Hepatitis / Will Irving, Kit Harling. Neonatal And Pediatric Infection / Deirdre Kelly, Elizabeth Boxall -- Management Of Hepatocellular Cancer / Helen L. Reeves, Jordi Bruix -- Application Of Molecular Biology To The Diagnosis Of Viral Hepatitis / Jean-michel Pawlotsky -- Hepatitis In Hiv-infected Persons / J. Main, B. Mccarron -- Treatment Of Extra-hepatic Diseases Caused By Hepatitis B And Hepatitis C Virus / Philippe Merle, Christian Trepo -- The Histologists Role In The Diagnosis And Management Of Chronic Hepatitis B & C / R Goldin, G Dusheiko -- Disinfection And Sterilization / Martin S. Favero, Walter W. Bond. Mechanisms Of Interferon Resistance / Darius Moradpour, Markus H. Heim, Hubert E. Blum -- New In Vitro Testing Systems For Hepatitis B And C Viruses / David Durantel ... [et Al.] -- New Vaccine Technologies And The Control Of Viral Hepatitis / Colin R. Howard -- Safety Of Hepatitis B Vaccines / Arie J. Zuckerman -- Before And Since The Discovery Of Australia Antigen : A Chronological Review Of Viral Hepatitis / Philip P. Mortimer, Arie J. Zuckerman. Edited By Howard Thomas, Stanley Lemon, Arie Zuckerman. Includes Bibliographical References And Index. Preface to the Third Edition......Page 8 Contributors......Page 10 I Introduction to Liver Biology......Page 16 1 Liver stem cells in persistent viral infection, liver regeneration and cancer......Page 18 2 Hepatic immunology......Page 30 II Clinical Aspects of Viral Hepatitis......Page 46 3 Clinical features of hepatitis......Page 48 4 Diagnostic approach to viral hepatitis......Page 65 5 Evolution of hepatitis viruses......Page 80 III Hepatitis A Virus......Page 92 6 Structure and molecular virology......Page 94 7 Epidemiology......Page 107 8 Natural history and experimental models......Page 124 9 Prevention......Page 141 IV Hepatitis B Virus and Other Hepadnaviridae......Page 162 10 Structure and molecular virology......Page 164 11 Epidemiology......Page 196 12 Avihepadnaviridae......Page 208 13 Woodchuck hepatitis virus......Page 225 14 Hepatitis B surface antigen (HBsAg) variants......Page 240 15 Molecular variations in the core promoter, precore and core regions of hepatitis B virus, and their clinical signifi cance......Page 257 16 Natural history of chronic hepatitis B and hepatocellular carcinoma......Page 278 17 Hepatocellular carcinoma: molecular aspects in hepatitis B......Page 284 18 Murine models and hepatitis B virus infection......Page 310 19 Pathogenesis of chronic hepatitis B......Page 323 20 Treatment of chronic hepatitis B......Page 338 21 Management of drug-resistant mutants......Page 352 22 Liver transplantation in the management of chronic viral hepatitis......Page 360 23 Prevention......Page 385 V Hepatitis C Virus......Page 394 24 Structure and molecular virology......Page 396 25 Epidemiology......Page 422 26 The immune response to hepatitis C virus in acute and chronic infection......Page 441 27 Natural history and experimental models......Page 454 28 Autoimmune disorders......Page 483 29 Central nervous system complications......Page 497 30 In vitro replication models......Page 511 31 Progression of fibrosis......Page 526 32 The natural history of hepatitis C and hepatocellular carcinoma......Page 535 33 Treatment of chronic hepatitis C......Page 541 34 New drugs for the management of hepatitis C......Page 555 35 Prevention......Page 568 VI Hepatitis D Virus......Page 584 36 Structure and molecular virology......Page 586 37 Epidemiology and natural history......Page 598 38 Treatment......Page 608 VII Hepatitis E Virus......Page 616 39 Structure and molecular virology......Page 618 40 Hepatitis E as a zoonotic disease......Page 626 41 Epidemiology, clinical and pathologic features, diagnosis, and experimental models......Page 639 42 Prevention......Page 650 VIII Clinical Aspects of Viral Liver Disease......Page 664 43 Aetiology of fulminant hepatitis......Page 666 44 Treatment of fulminant hepatitis......Page 681 45 Hepatitis and haemophilia......Page 697 46 Occupational aspects of hepatitis......Page 708 47 Neonatal and paediatric infection......Page 729 48 Management of hepatocellular cancer......Page 755 49 Application of molecular biology to the diagnosis of viral hepatitis......Page 770 50 Hepatitis in HIV-infected persons......Page 784 51 Treatment of extrahepatic diseases caused by hepatitis B and hepatitis C viruses......Page 795 52 The histologist’s role in the diagnosis and management of chronic hepatitis B and C......Page 809 53 Disinfection and sterilization......Page 819 54 Mechanisms of interferon resistance......Page 830 55 New in vitro testing systems for hepatitis B and C viruses......Page 839 56 New vaccine technologies and the control of viral hepatitis......Page 856 57 Safety of hepatitis B vaccines......Page 866 58 Before and since the discovery of Australia antigen: a chronological review of viral hepatitis......Page 869 Index......Page 880 Colour Plates......Page 892 There has been an explosion of both the incidence and medical knowledge of viral hepatitis over the last two decades. Not only is the incidence of infection and disease increasing, but new hepatitis viruses have been discovered, as well as the launch of new pharmaceutical products. Previously published by Churchill Livingstone, Viral Hepatitis by Zuckerman & Thomas was the first comprehensive book on hepatitis and is recognized as the standard reference text in this field. The new third edition, now published by Blackwell Publishing, addresses the recent advances in diagnosis and treatment with entirely revised and current topics. It covers the entire spectrum of viral hepatitis and has something of interest for every specialist. Viral Hepatitis presents the latest thinking from the leading international researchers and clinicians working in this field and the Editors are joined by a North American co-Editor for this edition - Professor Stanley Lemon of the University of Texas, Galveston, TX, USA. This book offers an ideal reference for all healthcare professionals involved in the research and patient care of this disease.