Vitamin-Binding Proteins : Functional Consequences

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD. Read more... Content: v. 1. Chemistry, metabolism, and circulation -- Mechanism of action -- Mineral homeostasis -- Target organs and tissues -- Human physiology -- v. 2. Diagnosis and management -- Disorders of the Vitamin D endocrine system -- New Vitamin D analogs -- Vitamin D and cancer -- Emerging uses. INTRODUCTION -- CH 1: Historical Perspective -- SECTION I: CHEMISTRY, METABOLISM, AND CIRCULATION -- CH 2: Vitamin D Metabolism -- CH 3: Photobiology of Vitamin D -- CH 4: The Vitamin D-25 Hydroxylase -- CH 5: The 25-Hydroxyvitamin D 1-alpha-Hydroxylase -- CH 6: The 25-Hydroxyvitamin D 24-Hydroxylase -- CH 7: Mutant Mouse Models of Vitamin D Metabolic Enzymes -- CH 8: Vitamin D Binding Protein -- CH 9: New Aspects of DBP -- CH 10: Endocytic Pathways for 25-(OH) Vitamin D3 -- SECTION II: MECHANISM OF ACTION -- CH 11: The Vitamin D Receptor -- CH 12: Vitamin D Receptor Promoter and Regulation of Receptor Expression -- CH 13: Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions -- CH 14: Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity -- CH 15: VDR LBD Crystal Structures -- CH 16: Comodulators of VDR-Mediated: Gene Expression -- CH 17: Promoter Targeting of VDR Through A Chromatin Remodeling Complex -- CH 18: Molecular Basis of the Diversity of Vitamin D Target Genes -- CH 19: Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of Skeletal Gene -- CH 20: Mouse Models of Vitamin D Receptor Ablation -- CH 21: Intranuclear Vitamin D Response Element Binding -- CH 22: VDR and RXR Subcellular Trafficking -- CH 23: 1a,25(OH)2ŁVvitamin D3 mediated rapid and genomic responses are dependent upon critical structure-function relationships for both the ligand and receptor(s) -- SECTION III: MINERAL HOMEOSTASIS -- CH 24: Vitamin D and the Intestinal Absorption of Calcium: A View and Overview -- CH 25: Intestinal Calcium Absorption: Lessons from Knock Out Mice and Men -- CH 26: Phosphate Homeostasis -- CH 27: Mineralization -- CH 28: Modeling and Remodeling: How Bone Cells Work Together -- CH 29: Vitamin D and the Kidney -- CH 30: Vitamin D and the Parathyroids -- CH 31: Calcium-Sensing Receptor -- SECTION IV: TARGET ORGANS AND ACTIONS: -- A. Organs/Tissues -- CH 32: Bone -- CH 33: Cartilage and Vitamin D: Genomic and Nongenomic Regulation -- CH 34: Dento-Alveolar Bone Complex and Vitamin D -- CH 35: Role in Skin and Hair -- CH 36: Regulation of Immune Responses by Vitamin D Receptor Ligands -- CH 37: Osteoblasts -- CH 38: Vitamin D and Osteoclastogenesis -- CH 39: Vitamin D Control of the Calcitonin Gene in Thyroid C Cells -- CH 40: Vitamin D Regulation of Type I Collagen Expression in Bone -- CH 41: Target Genes: Bone Proteins -- CH 42: The Calbindins: Calbindin-D9k and Calbindin-D28k -- CH 43: Target Genes -- CH 44: Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in the Vitamin D Endocrine System -- CH 45: Vitamin D and the Cellular Response to Oxidative Stress -- SECTION V: HUMAN PHYSIOLOGY -- CH 46: Vitamin D: Role in the Calcium Economy -- CH 47: Effects of Race, Geography, Body Habitus, Diet, and Exercise on Vitamin D Metabolism -- CH 48: Perinatal Vitamin D Actions -- CH 49: Vitamin D Deficiency and Calcium Absorption During Infancy and Childhood -- CH 50: Vitamin D Metabolism and Aging -- CH 51: Vitamin D Metabolism in Pregnancy and Lactation -- CH 52: Vitamin D and Reproductive Organs -- CH 53: Vitamin D Receptor as a Sensor for Toxic Bile Acids -- CH 54: The Renin-Angiotensin System -- CH 55: Vitamin D and Muscle -- CH 56: Vitamin D and Cardiovascular Medicine -- SECTION VI: DIAGNOSIS AND MANAGEMENT -- CH 57: Approach to the Patient with Metabolic Bone Disease -- CH 58: Detection of Vitamin D and Its Major Metabolites -- CH 59: Bone Histomorphometry -- CH 60: Radiology of Rickets and Osteomalacia -- CH 61: The Pharmacology of Vitamin D, Including Fortification Strategies -- SECTION VII: DISORDERS OF THE VITAMIN D: ENDOCRINE SYSTEM -- CH 62: How to Define Normal Values for Serum Concentrations of 25-Hydroxyvitamin D? An Overview -- CH 63: Vitamin D and the Pathogenesis of Rickets and Osteomalacia -- CH 64: The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D -- CH 65: Vitamin D Deficiency and Nutritional Rickets in Children -- CH 66: Vitamin D Insufficiency in Adults and the Elderly -- CH 67: Vitamin D and Osteoporosis -- CH 68: Genetic Vitamin D Receptor Polymorphisms and Risk of -- CH 69: Clinical Disorders of Phosphate Homeostasis -- CH 70: Disorders of Phosphate Metabolism: Autosomal Dominant Hypophosphatemic Rickets, Tumor Induced Osteomalacia, Fibrous Dysplasia, and the Pathophysiological Relevance of FGF23 TIO, ADDR FGF-23 -- CH 71: Vitamin D Pseudodeficiency -- CH 72: Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets -- CH 73: Glucocorticoids and Vitamin D -- CH 74: Drug and Hormone Effects on Vitamin D Metabolism -- CH 75: Bone Disorders Associated with Gastrointestinal & Hepatobiliary Disease -- CH 76: Vitamin D and Renal Failure -- CH 77: Idiopathic Hypercalciuria and Nephrolithiasis -- CH 78: Hypercalcemia Due to Vitamin D Toxicity -- CH 79: Extra-renal 1þ-hydroxylase Activity and Human Disease -- SECTION VIII: NEW VITAMIN D ANALOGS -- CH 80: Overview: Rational Design of 1a,25-Dihydroxyvitamin D3 Analogs (Deltanoids) -- CH 81: Analog Metabolism -- CH 82: Mechanisms for the Selective Actions of Vitamin D Analogs -- CH 83: Molecular Basis for Differential Action of Vitamin D Analogs -- CH 84: Development of New Vitamin D Analogs -- CH 85: Geminis: The 1,25-dihydroxy Vitamin D Analogs with Two Side-Chains -- CH 86: Development of OCT and ED-71 -- CH 87: 2-Carbon-Modified Analogs of 19-Nor- 1a,25-Dihydroxyvitamin D3 -- CH 88: Non-steroidal Analogs -- SECTION IX: VITAMIN D AND CANCER -- CH 89: Vitamin D: Cancer and Differentiation -- CH 90: Vitamin D, Sunlight, and the Natural History of Prostate Cancer -- CH 91: Epidemiology of Cancer Risk: Vitamin D and Calcium -- CH 92: Differentiation and the Cell Cycle -- CH 93: Vitamin D and Breast Cancer -- CH 94: Vitamin D and Prostate Cancer -- CH 95: Vitamin D and Colon Cancer -- CH 96: Vitamin D and Hematological: Malignancy -- CH 97: Clinical Development of Calcitriol and Calcitriol Analogs in Oncology: Progress and Considerations for Future Development -- SECTION X: EMERGING USES: -- Overview: Vitamin D Vs. Calcium Effects -- CH 98: Vitamin D3: Autoimmunity and Immunosuppression -- CH 99: Vitamin D and Diabetes -- CH 100: Vitamin D, A Neuroactive Hormone: From Brain Development to Neurodegenerative Disorders -- CH 101: Psoriasis and Other Skin Diseases -- CH 102: Muscles and Falls -- CH 103: Renal Failure and Secondary Hyperparathyroidism -- CH 104: Inhibition of Benign Prostatic Hyperplasia by Vitamin D Receptor Ligands. Abstract: Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD Diverse in chemical nature, water soluble and lipid soluble vitamins are essential micronutrients that react with specific protein entities and are transported to sites for participation in intracellular events, both at the genomic and non-genomic levels. Thus, metabolic pathways and intracellular signaling are influenced by vitamins or their derivatives through vitamin binding to specific proteins. Vitamin-Binding Proteins: Functional Consequences examines the function of various vitamins based on this binding, as well as their role as antioxidants, leading to effects on intracellular mechanisms. This book explores the resulting functional consequences at the level of cells, tissues, and organs as well as the neurological, endocrine, and immune systems. The text addresses the effects that lead to both normal physiological function and pharmacological activity with significant therapeutic potential in a wide spectrum of disease processes. Leading experts discuss various vitamins including the function of retinoids in development, immunity, and obesity; the role of vitamin D in the immune system, infectious processes, and cardiovascular disease; and the effects of vitamins E, C, and K on the vascular system. Chapters cover the therapeutic potential of the vitamin B 6 vitamer pyridoxamine and the lipid-soluble B 1 analogue benfotiamine. They also describe various functions of biotin as well as gene transcriptional regulation through biotin and biotin-binding proteins. The text addresses folate receptor-mediated therapeutics, vitamin B 12 derivatives in tumor targeting, and implication of ascorbic acid in different disorders. Expounding newer areas of vitamin function, this book explores the interface of physiological vitamin function and pharmacological vitamin action, offering a broad perspective of possible vitamin binding therapeutics. Diverse in chemical nature, water soluble and lipid soluble vitamins are essential micronutrients that react with specific protein entities and are transported to sites for participation in intracellular events, both at the genomic and non-genomic levels. Thus, metabolic pathways and intracellular signaling are influenced by vitamins or their derivatives through vitamin binding to specific proteins. Vitamin-Binding Proteins: Functional Consequences examines the function of various vitamins based on this binding, as well as their role as antioxidants, leading to effects on intracellular mechanisms. This book explores the resulting functional consequences at the level of cells, tissues, and organs as well as the neurological, endocrine, and immune systems. The text addresses the effects that lead to both normal physiological function and pharmacological activity with significant therapeutic potential in a wide spectrum of disease processes. Leading experts discuss various vitamins including the function of retinoids in development, immunity, and obesity; the role of vitamin D in the immune system, infectious processes, and cardiovascular disease; and the effects of vitamins E, C, and K on the vascular system. Chapters cover the therapeutic potential of the vitamin B 6 vitamer pyridoxamine and the lipid-soluble B 1 analogue benfotiamine. They also describe various functions of biotin as well as gene transcriptional regulation through biotin and biotin-binding proteins. The text addresses folate receptor-mediated therapeutics, vitamin B 12 derivatives in tumor targeting, and implication of ascorbic acid in different disorders. Expounding newer areas of vitamin function, this book explores the interface of physiological vitamin function and pharmacological vitamin action, offering a broad perspective of possible vitamin binding therapeutics V. 1. Chemistry, Metabolism, And Circulation -- Mechanism Of Action -- Mineral Homeostasis -- Target Organs And Tissues -- Human Physiology -- V. 2. Diagnosis And Management -- Disorders Of The Vitamin D Endocrine System -- New Vitamin D Analogs -- Vitamin D And Cancer -- Emerging Uses. Editor-in-chief, David Feldman ; Associate Editors, J. Wesley Pike, Francis H. Glorieux. Includes Bibliographical References And Index. System Requirements For Windows: Windows 98, Windows 2000, Windows Me, Or Windows Xp; Pentium Ii Processor; 233 Mhz Or Higher; 64 Mb Of Available Ram; 2 Mb Of Available Hard-disk Space; 8x Or Faster Cd-rom Drive; Vga Monitor Supporting 256 Colors; 800 X 600 Screen Resolution; Internet Explorer 5.0 Or Later. System Requirements For Macintosh: Apple Powerpc 166 Mhz Or Higher; Mac Os Version 9.1 Or Higher; 64 Mb Of Available Ram; 2 Mb Of Available Hard-disk Space; 8x Or Faster Cd-rom Drive; Vga Monitor Supporting 256 Colors; 800 X 600 Screen Resolution; Netscape 4.76 Or Later. Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.

*Most comprehensive, up-to-date two-volume set on Vitamin D
*New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more
*Further sections on emerging uses for treatments of auto-immune diseases and diabetes
*Over 600 illustrations and figures available on CD Minor changes in the chemical structure of vitamins can cause major differences in their binding to proteins and therefore in their biological function. This book summarizes the current knowledge base with regard to vitamin-binding proteins. It stresses the ways in which vitamin bonds to proteins offer therapeutic potential for various diseases