Animal models in cardiovascular research

Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the first edition of this textbook. This completely revised and updated text provides information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation have been changed to make the text more easy to read and use. An introductory chapter offers general principles of animal selection, pre and post-operative care, preanesthesia, chemical restraint, analgesia, and the recognition of pain. The number of references cited has been almost doubled over the previous text and the chapter tabulating normal cardiovascular parameters from intact, awake animals, of those species commonly used in research, has been greatly expanded. Other chapters providing comprehensive data on the cardiovascular effects of opioids, tranquilizers, anesthetic agents and other drugs commonly used in cardiovascular research have been expanded with special emphasis on species variability to drug effects. The chapters on both naturally occurring and iatrogenic models of cardiovascular disease have also been expanded and updated. Front Matter....Pages i-xvii General principles of animal selection, preoperative care, preanesthesia, chemical restraint and analgesia....Pages 1-12 Cardiovascular effects of the opiods....Pages 13-68 Cardiovascular effects of the tranquilizers....Pages 69-123 Cardiovascular effects of other drugs commonly used in cardiovascular research....Pages 125-185 General anesthesia....Pages 187-192 Cardiovascular effects of intravenous anesthetic agents....Pages 193-233 Cardiovascular effects of inhalant anesthetic agents....Pages 235-301 Cardiovascular effects of hallucinogens, neurolept analgesic/anesthetic combinations and steroid anesthetics....Pages 303-342 Normal cardiovascular parameters from intact, awake animals....Pages 343-402 Naturally occurring models of cardiovascular disease....Pages 403-419 Iatrogenic models for studying heart disease....Pages 421-461 Animal models of atherosclerosis....Pages 463-474 Animal models of hypertension....Pages 475-482 Back Matter....Pages 483-501