Osteoporosis Research : Animal Models

__Osteoporosis Research - Animal Models,__ presents in a very illustrative and practical manner, general methodologies of bone studies in animals, as well as the particular features of the most commonly used animal models in the field. Research in the field of osteoporosis has grown in recent years. This has resulted in significant advances in determining the causes of osteoporosis, assessing risk factors, and creating new treatment methods. The use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in both humans and animals. __Osteoporosis Research - Animal Models,__ is an essential tool for researchers in the bone field. This book aids researchers in selecting their appropriate model and highlights the experiments that can be strategically designed to optimize the potential of an animal to develop the cardinal features of osteoporosis in humans. This book addresses the importance of recent findings from animal models and their significance on the pathogenesis of osteoporosis in relation to human disease. Osteoporosis Research – Animal Models is a reference book of the major animal models used in the study of Osteoporosis. Use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in both humans and animals. This book is directed primarily toward endocrinologists, rheumatologists, geriatricians, gerontologists, bone biologists, investigators, research fellows, graduate students, and those working in osteoporosis research. This book is intended to serve as a basis for a literature search before embarking on a detailed research project. Osteoporosis Research – Animal Models includes the most up-to-date and practical information to guide the investigator on the most appropriate mouse model to test the hypothesis. This book is written by investigators within the field of bone research who have published extensively on their own developed or commonly used animal models for osteoporosis. The institutions where the authors are affiliated are highly recognized as the main centers in bone research. Front Matter....Pages i-xix How to Select Your Animal Model for Osteoporosis Research....Pages 1-12 Skeletal Phenotyping in Rodents: Tissue Isolation and Manipulation....Pages 13-28 Methods in Bone Biology in Animals: Biomechanics....Pages 29-36 Methods in Bone Histomorphometry for Animal Models....Pages 37-43 Methods in Bone Biology in Animals: Imaging....Pages 45-56 Methods in Bone Biology in Animals: Biochemical Markers....Pages 57-82 Methods in Bone Biology: Cancer and Bone....Pages 83-91 How to Test Osteoporosis Treatments in Experimental Animals....Pages 93-99 The Ovariectomized Mice and Rats....Pages 101-114 Classical Models of Senile Osteoporosis....Pages 115-121 Animal Models of Premature Aging....Pages 123-134 Nonhuman Primate Models of Osteoporosis....Pages 135-157 Other Large Animal Models....Pages 159-174 Mouse models for the Study of Fracture Healing and Bone Regeneration....Pages 175-191 Back Matter....Pages 193-196