Epigenetic Gene Expression and Regulation

__Epigenetic Gene Expression and Regulation__ reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. * Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies * Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring * Chapters are replete with clinical examples to empower the basic biology with translational significance * Offers more than 100 illustrations to distill key concepts and decipher complex science Content: Translational Epigenetics Series,Front Matter,Copyright,Contributors,Preface,AcknowledgmentEntitled to full textChapter 1 - Epigenetic gene expression—an introduction, Pages 1-19, C. Ann Blakey, Michael D. Litt Chapter 2 - Histone modifications—models and mechanisms, Pages 21-42, C. Ann Blakey, Michael D. Litt Chapter 3 - Genomic imprinting in mammals—memories of generations past, Pages 43-61, Nora Engel Chapter 4 - Polycomb and Trithorax factors in transcriptional and epigenetic regulation, Pages 63-94, Priscilla Nga Ieng Lau, Chi Wai Eric So Chapter 5 - Chromatin dynamics and genome organization in development and disease, Pages 95-115, Changwang Deng, Bhavita Patel, Xiumei Lin, Yangqiu Li, Suming Huang Chapter 6 - ncRNA function in chromatin organization, Pages 117-148, Keith E. Giles, Jessica L. Woolnough, Blake Atwood Chapter 7 - Epigenetic gene regulation and stem cell function, Pages 149-181, Aissa Benyoucef, Marjorie Brand Chapter 8 - Epigenetic inheritance, Pages 183-208, Benjamin B. Mills, Christine M. McBride, Nicole C. Riddle Chapter 9 - Transgenerational epigenetic regulation by environmental factors in human diseases, Pages 209-222, Yuanyuan Li Chapter 10 - Identification of intergenic long noncoding RNA by deep sequencing, Pages 223-235, Gangqing Hu, Keji Zhao Chapter 11 - Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA, Pages 237-264, Alex Xiucheng Fan, Mir A. Hossain, Jared Stees, Ekaterina Gavrilova, Jörg Bungert Chapter 12 - Genetically altered cancer epigenome, Pages 265-289, Ming Tang, Huacheng Luo, Jianrong Lu Chapter 13 - Long noncoding RNAs and carcinogenesis, Pages 291-312, Félix Recillas-Targa Chapter 14 - Epigenetics of physiological and premature aging, Pages 313-338, Shrestha Ghosh, Zhongjun Zhou Chapter 15 - Epigenetic effects of environment and diet, Pages 339-365, Jason O. Brant, Thomas P. Yang Chapter 16 - Epigenetic control of stress-induced apoptosis, Pages 367-377, Lei Zhou Chapter 17 - Structure, regulation, and function of TET family proteins, Pages 379-395, Xin Hu, Yun Chen, Zhizhuang Joe Zhao Chapter 18 - Epigenetic drugs for cancer therapy, Pages 397-423, Bowen Yan, Xuehui Li, Alta Johnson, Yurong Yang, Wei Jian, Yi Qiu List of acronyms and abbreviations, Pages 425-444 Glossary, Pages 445-451 Index, Pages 453-461

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies.

The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.

The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.

Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.

• Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies
• Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring
• Chapters are replete with clinical examples to empower the basic biology with translational significance
• Offers more than 100 illustrations to distill key concepts and decipher complex science