Gene expression and regulation

All genes must be expressed to exhibit their biological activities. How genes are expressed and regulated is a central question in molecular biology and our knowledge in this area has been expanding enormously in recent years. The complexity of gene regulation is compounded by the fact that gene activities reach every comer of biology. Transcription is universally the first step toward expressing a gene. It is a highly regulated process. Understanding the molecular mechanisms of transcription regulation is of fiindamental importance. For protein-coding genes, post-transcriptional steps, including pre-mRNA processing, mRNA transport and translation, can also play important roles in regulating gene expression. To contain the scope of this book, we will focus primarily on RNA polymerase II transcription and regulation. We will explore not only the biochemical basis of transcription but also the biological consequences of, and biological influences on gene transcription. The book is composed of 35 individual review articles written by authorities in the field. The chapters are organized into five sections: The History, The Machinery, The Regulators, The Genome, and Special Topics. The History section contains one chapter, written by James Goodrich and Robert Tjian, who provide an excellent historical perspective and overview of the transcription process. The Machinery section has six chapters that cover essential topics on the transcriptional apparatus, general cofactors, chromatin structure, and core promoter structure.

this Book Offers A Comprehensive Look Into The Science Of Gene Expression And Regulation. Focusing On Topics Such As Actions Of Nuclear Receptors, Rna Processing, And Dna Methylation And Imprinting, Gene Expression And Regulation Is Edited By A Leading Biologist And Includes Contributions By Experts In The Field.

presented In The Following Five Sections, This Book Covers A Full Spectrum Of Topics: The History; The Machinery; The Regulators; The Genome; And Special Topics. The Machinery Section Covers The Transcriptional Apparatus And General Transcription Factors. The Regulators Section Examines Selected Gene-specific Transcription Factors Important To Regulating Gene Expression. The Genome Section Covers Issues Relevant To The Behavior Of The Genome In Relation To Gene Regulation. The Special Topics Section Discusses Several Selected Topics Ranging From Bacterial And Plant Gene Expression To Dna Topology And Interference Rna. The Book’s Focus Is On Scientific Concepts And Issues, Rather Than Specific Organisms Or Experimental Approaches.

complete With More Than 100 Illustrations, Gene Expression And Regulation Provides Biologists With Concise And Comprehensive Research Outlined In Chapters Including:

• Dna Topology And Transcription

• Gene Expression In Plants

• Chromatin And Chromatin Remodeling

• Core Promoter Elements

• Bacterial Gene Regulation

• Transcription Factor Dynamics

"This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. Presented in the following five sections, this book covers a full spectrum of topics: The History; The Machinery; The Regulators; The Genome; and Special Topics. The Machinery section covers the transcriptional apparatus and general transcription factors. The Regulators section examines selected gene-specific transcription factors important to regulating gene expression. The Genome section covers issues relevant to the behavior of the genome in relation to gene regulation. The Special Topics section discusses several selected topics ranging from bacterial and plant gene expression to DNA topology and interference RNA. The book's focus is on scientific concepts and issues, rather than specific organisms or experimental approaches. Complete with more than 100 illustrations, Gene Expression and Regulation provides biologists with concise and comprehensive research outlined in chapters including: DNA Topology and Transcription; Gene Expression in Plants; Chromatin and Chromatin Remodeling; Core Promoter Elements; Bacterial Gene Regulation; Transcription Factor Dynamics."--Publisher's description This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches. Organized In Four Sections Covering A Spectrum Of Topics Relevant To Gene Expression And Regulation, With Contributions By Experts In The Field. This Book Features Areas Such As: The Machinery; The Regulators; The Genome; And Special Topics. It Focuses On Scientific Concepts And Issues, Rather Than Specific Organisms Or Experimental Approaches. Offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, this book focuses on scientific concepts and issues, rather than specific organisms or experimental approaches.