The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease. Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function. Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed. Although the question why some of the mutations in gap-junction proteins lead to a specific phenotype remains to be answered, the reviews in this book give an intriguing outlook on the future direction of this research field. Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field. Connexin and Pannexin Genes in the Mouse and Human Genome....Pages 1-12 Essential Role of Gap Junctions During Development and Regeneration of Skeletal Muscle....Pages 13-27 Connexins in Cardiac Development: Expression, Role, and Transcriptional Control....Pages 29-55 Gap Junction and Connexin Remodeling in Human Heart Disease....Pages 57-82 Gap Junction Expression in Brain Tissues with Focus on Development....Pages 83-110 Connexins Responsible for Hereditary Deafness — The Tale Unfolds....Pages 111-134 Human Connexins in Skin Development and Skin Disorders....Pages 135-171 Intercellular Communication in Lens Development and Disease....Pages 173-195 Connexin Modulators of Endocrine Function....Pages 197-221 Roles of Gap Junctions in Ovarian Folliculogenesis: Implications for Female Infertility....Pages 223-237 Placental Connexins of Mice and Men....Pages 239-252 Connexins in Growth Control and Cancer....Pages 253-273 Reviewing various mouse and human genes encoding the channel-forming connexins, this book also describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. It also addresses the issue of erroneous signaling mediated by the interaction of mutant connexins with other proteins.
