“This volume presents an excellent overview into the world of cell adhesion. It provides important details about the main players in all aspects of cell junctions.” –The Quarterly Review of Biology, September 2009 Eagerly awaited, this comprehensive book on a topic of fundamental importance in our understanding of cancer begins with an overview of cellular junctions, before covering in detail cell-matrix junctions, cell-cell junctions as well as cell-matrix and cell-cell adhesion. This reference work is of high interest to cell and molecular biologists, cancer researchers, oncologists, biochemists, pharmaceutists and those working in the pharmaceutical industry.
“this Volume Presents An Excellent Overview Into The World Of Cell Adhesion. It Provides Important Details About The Main Players In All Aspects Of Cell Junctions.” –the Quarterly Review Of Biology, September 2009
eagerly Awaited, this Comprehensive Book On a Topic Of Fundamental Importance In Our Understanding Of Cancer Begins With An Overview Of Cellular Junctions, Before Covering In Detail Cell-matrix Junctions, cell-cell Junctions As Well As cell-matrix And Cell-cell Adhesion.
this Reference Work is Of High Interest To Cell And Molecular Biologists, Cancer Researchers, Oncologists, Biochemists, Pharmaceutists And Those Working In The Pharmaceutical Industry.
doody Review Services
reviewer:bruce A. Fenderson, Phd(thomas Jefferson University)
description:cell Junctions Are Clusters Of Proteins That Provide Adhesive Contacts Between Cells And Their Environment. These Receptors And Transmembrane Signaling Molecules Play A Key Role In Regulating Morphogenesis, Differentiation, And Wound Healing. As Noted By The Editors, Cell Junctions Not Only Mediate Physical Interactions, But Also Couple Cell Contact To Signaling Pathways That Influence Cell Shape, Cell Cycle Progression, And Gene Expression. This Book Reviews The Literature On Cell Junctions In Development And Disease, With 14 Concise Chapters On Topics Ranging From Cell Matrix Adhesion In Three Dimensions To Cadherin Trafficking And Junction Dynamics. The Emphasis Is On Cell Biology And Protein Biochemistry.
purpose:the Purpose Is To Assemble Important Contributions From Some Of The World's Leading Experts Into One Book. The Authors Hope This Book Will Provide A Resource That Is Valuable To The New Student Of Cell Junctions, And To Experienced Scientists In The Field, And To Those Educators Who Require A Comprehensive Assembly Of Overviews In The Discipline Of Cell Contact And Adhesion. The Authors Are Experts In This Exciting, Interdisciplinary Field.
audience:the Book Is Written For Basic Science And Clinical Researchers (graduate Students, Postdoctoral Fellows, And Scientists) Interested In Cell/developmental Biology, Biochemistry, Biophysics, And Bioengineering. Oncologists And Those Working In The Pharmaceutical Industry Will Also Appreciate This In-depth Overview Of The Cell Adhesion Literature.
features:the Authors Wish To Understand How Cell Junction Signaling Changes During Development And How Defects In Cell Junction Signaling Contribute To Disease. The Book Is Divided Into Three Major Sections: L) Cell-matrix Junctions With An Emphasis On Integrins; 2) Cell-cell Junctions With An Emphasis On Cadherins; And 3) Cross-talk Between These Two Types Of Cell Surface Contacts. This Is Not A Protocol Book, But An Up-to-date Review Of The Literature. Each Chapter Begins With An Introduction And Concludes With A Brief Summary Or Discussion Of Future Research Prospects. Results Of Gene Knockout Studies Are Provided For Key Proteins. The Line Drawings And Photomicrographs Are Informative And Well Done, And Several Figures Are Printed In Full Color. The Authors Provide Complete References To Facilitate Scholarly Research.
assessment:the Chapters Are Readable Accounts Of A Very Rich And Complicated Literature. The Authors Illustrate How Cell Surface Proteins Integrate Signals To Coordinate Complex Processes Such As Cell Migration And Morphogenesis. The Chapters Are Well Written And The Book Is Carefully Edited. The Excellent Preface Helps Place The Individual Chapters Into Perspective. The Authors Focus On Important Topics And Provide A Snapshot Of Current Research Findings. An Important Feature Of This Book Is The Focus On Cell Junctions In Health And Disease (i.e., Clinical Correlations). This Is A Welcome Addition To The Literature That Will Be Valued By All Students Of Cell Adhesion And Morphogenesis.
This Novel, Multidisciplinary Handbook Highlights Recent Evidence That Antigen Presenting Cells (apcs) Are Not Only Key Players In The Initiation Or Prevention Of An Antigen-specific T Lymphocyte-mediated Adaptive Immune Response, But Also Critical Regulators And Integrators In The Interplay Between Our Innate And Adaptive Immune System. Structured In A Clear Way To Allow Access To A Very Broad Readership, The Book Is Written From The Viewpoint Of A Biochemist, Immunologist, And Scientist With Experience In Drug Development. It Covers All Cell Types Involved In Antigen Presentation, Providing. Pt. I. Antigen Presentation In The Immune System, 1. Some Old Some New Findings On Atigen Processing And Presentation / Emil R. Unanue -- Pt. Ii. Molecular Mechanisms Of Antigen Processing, 2. Antigen Entry Routes : Where Foreign Invaders Meet Antigen Presenting Cells / Percy A. Knolle ; 3. Antigen Processing In The Context Of Mhc Class I Molecules / Frank Momburg ; 4. Antigen Processing For Mhc Class Ii / Anne B. Vogt ... Et Al. ; 5. Antigen Processing And Presentation By Cd1 Family Proteins / Steven A. Porcelli And D. Branch Moody -- Pt. Iii. Antigen Presenting Cells' Ligands Recognized By T- And Toll-like Receptors, 6. Naturally Processed Self-peptides Of Mhc Molecules / Harald Kropshofer And Sebastian Spindeldreher ; 7. Target Cell Contributions To Cytotoxic T Cell Sensitivity / Tatiana Lebdeva ... Et Al. ; 8. Stimulation Of Antigen Presenting Cells : From Classical Adjuvants To Toll-like Receptor (tlr) Ligands / Martin F. Bachmann And Annette Oxenius -- Pt. Iv. The Repertoire Of Antigen Presenting Cells, 9. Evolution And Diversity Of Macrophages / Nicholas S. Stoy ; 10. Macrophages : Balancing Tolerance And Immunity / Nicholas S. Stoy ; 11. Polymorphonuclear Neutrophils An Antigen-presenting Cells / Amit R. Ashtekar And Bhaskar Saha ; 12. Microglia : The Professional Antigen-presenting Cells Of The Cns? / Monica J. Carson ; 13. Contribution Of B Cells To Autoimmune Pathogenesis / Thomas Dörner And Peter E. Lipsky ; 14. Dendritic Cells (dcs) In Immunity And Maintenance Of Tolerance / Magali De Heusch ... Et Al. ; 15. Tymic Dendritic Cells / Kenneth Shortman And Li Wu -- Pt. V. Antigen Presenting Cell-based Drug Development, 16. Antigen Presenting Cells And Drug Targets. Edited By Harald Kropshofer And Anne B. Vogt. Includes Bibliographical References And Index. Also Available In An Electronic Version. Mode Of Access: World Wide Web. Cell Migration Matches Nearly All Research Areas In Cell And Developmental Biology, Genetics, And Biomedicine. The Field Shows Radical Progress Powered By The Combination Of New Genomic Tools, Cell Labeling Techniques And The Incorporation Of New Model Systems. This Is The First Book To Comprehensively Cover Cell Migration From The Identification Of Molecular Mechanisms To The Understanding Of Certain Pathological Disorders And Cancer Development. Functional Phases In Cell Attachment And Spreading / Michael P. Sheetz, Benjamin J. Dubin-thaler, Gregory Giannone, Guoying Jiang, And Hans-gunther Dobereiner -- Polarized Cell Motility: Microtubules Show The Way / J. Victor Small And Irina Kaverina -- Mechanisms Of Eukaryotic Chemotaxis / Chris Janetopoulos, Yu Long, And Peter Devreotes -- Dual Location Proteins: Communication Between Cell Adhesions And The Nucleus / Erin G. Cline And W. James Nelson -- Cell Migration During Zebrafish Gastrulation / Irinka Castanon And Carl-philipp Heisenberg -- Aspects Of The Origin And Function Of Cell Mediolateral Intercalation Behavior (mib) During Convergent Extension / Ray Keller -- On The Border Of Understanding Cell Migration / Jocelyn A. Mcdonald And Denise J. Montell -- Glia Cell Migration In Drosophila / Gundula Edenfeld And Christian Klambt -- The Neural Crest: Migrating From The Border / Marianne Bronner-fraser -- Primordial Germ Cell Migration In Zebrafish / Erez Raz -- Hgf/sf C-met Signaling In The Epithelial-mesenchymal Transition And Migration Of Muscle Progenitor Cells / Ute Schaeper And Walter Birchmeier -- Host-pathogen Interactions And Cell Motility: Learning From Bacteria / Theresia E.b. Stradal, Silvia Lommel, Jurgen Wehland, And Klemens Rottner -- Transendothelial Migration Of Leukocytes / William A. Muller And Alan R. Schenkel -- Chemokine-controlled Migration In Lymphoid Organogenesis And The Systemic Organization Of Immunity / Martin Lipp -- Keratinocyte Migration In Wound Healing / Cord Brakebusch -- From Tumorigenesis To Tumor Progression: Signaling Pathways Driving Tumor Invasion And Metastasis / Klaudia Giehl, Andre Menke, Doris Wedlich, Michael Beil And Thomas Seufferlein. Edited By Doris Wedlich. Includes Bibliographical References And Index. Also Available In An Electronic Version. Mode Of Access: World Wide Web. Combining A Comprehensive Treatment Of Both Embryogenesis And Organ Development In One Reference Work, This Handbook Is Structured According To Organ Systems. It Addresses The Functions Of All Signaling Pathways And Growth Factors Important For The Development Of The Embryo And The Adult. With Its Focus On Vertebrates, This Volume Provides An Overview Of The Molecular Communication Regulating Such Processes As Cell Division, Migration, And Differentiation. Additionally, Sections On Developmental Disorders And Related Novel Therapeutic Strategies Highlight Applications In Molecular Medicine. Stem Cells -- Germ Cells -- Implantation And Placentation -- Cell Movements During Early Vertebrate Morphogenesis -- Head Induction -- Anterior-posterior Patterning Of The Hindbrain: Integrating Boundaries And Cell Segregation With Segment Formation And Identity -- Neurogenesis In The Central Nervous System -- Generating Cell Diversity -- The Molecular Basis Of Directional Cell Migration -- Cell Dealth In Organ Development -- Dorso-ventral Patterning Of The Vertebrate Central Nervous System -- Novel Perspectives In Research On The Neural Crest And Its Derivatives -- Eye Development -- Mammalian Inner Ear Development: Of Mice And Man -- Limb Development -- Skeletal Development -- Musculature And Growth Factors -- Skin Development -- Tooth Development -- Gastrointestinal Tract -- Cell Signaling And Growth Factors In Lung Development -- Molecular Genetics Of Liver And Pancreas Development -- Molecular Networks In Cardiac Development -- Vasculogenesis -- Inductive Signaling In Kidney Morphogenesis -- Molecular And Cellular Pathways For The Morphogenesis Of Mouse Sex Organs. Edited By Klaus Unsicker And Kerstin Krieglstein. Includes Bibliographical References And Index. v. 1. Adipocytes to biological regulation by protein phosphorylation v. 2. Bioorganic chemistry to chamydomonas v. 3. Chromosome organization within the nucleus to E-cell : computer simulation of the cell v. 4. Electric and magnetic field reception to FTIR of biomolecules v. 5. Fungal biotechnology to growth factors v. 6. Growth factors and oncogenes in gastrointestinal cancers to informatics (computational biology) v. 7. Innate immunity to mass spectrometry, high speed DNA fragment sizing v. 8. Mass spectrometry-based methods of proteome analysis to mucoviscidosis (cystic fibrosis), molecular cell biology of v. 9. Mutagenesis, malignancy and genome instability to organic cofactors as coenzymes v. 10. Origins of life, molecular basis of to programmed cell death. v. 11. Proteasomes to receptor, transporter and ion channel diseases. v. 12. Recombination and genome rearrangements to serial analysis of gene expression. v. 13. Sex hormones (male) : analogs and antagonists to synchrotron infrared microspectroscopy. v. 14. Syngamy and cell cycle control to triacylglyerol storage and mobilization, regulation of. v. 15. Triplet repeat diseases to zebrafish (danio rerio) genome and genetics. v. 16. Index. "This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system." "Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providing the latest immunological facts with a focus on drug development. Backed by a glossary explaining all important technical terms, this short but comprehensive reference covers basic introductory aspects right up to details for advanced specialists."--BOOK JACKET Die Zellmigration ist in nahezu allen Bereichen der Entwicklungsbiologie, Genetik und Biomedizin von Bedeutung. Neue Verfahren zur Zellmarkierung und neue Modellsysteme führten zu raschen Fortschritten bei der Erforschung der molekularen Mechanismen der Wanderung von Zellen. Dieser Band handelt alle Aspekte des Themas umfassend ab. Im letzten Kapitel wird die Rolle der Zellmigration bei der Entstehung bestimmter Krankheitsbilder (unter anderem von Tumoren) diskutiert. Die beiliegende CD-ROM enthält faszinierende Animationen von Migrationsprozessen This long-awaited, first comprehensive book on this topic of fundamental importance in our understanding of cancer begins with an overview of cellular junctions, before covering cell-matrix junctions, cell-cell junctions and cell-matrix and cell-cell adhesion in separate sections.Of high interest to cell and molecular biologists, cancer researchers, oncologists, biochemists, pharmaceutists and those working in the pharmaceutical industry
