Hematology : basic principles and practice

Univ. of Illinois, Chicago. Text/reference on the science and practice of hematology. For practitioners, students, residents, fellows, and researchers. Includes many new chapters and over thirty new contributors. Two-tone format with halftone illustrations. Extensive references. DNLM: Hematologic Diseases--diagnosis. HEMATOLOGY Basic Principles and Practice 5 Preface to the Third Edition 23 Preface to the Second Edition 24 Preface to the First Edition 25 Color Plates 27 Part I - Molecular and Cellular Basis of Hematology Chapter 1 - Anatomy and Physiology of the Gene 36 Chapter 2 - Protein Synthesis and Intracellular Sorting 52 Chapter 3 - Protein Architecture: Relationship of Form and Function 66 Chapter 4 - Plasma Membrane Dynamics and Organization 76 Chapter 5 - Cell Adhesion 87 Chapter 6 - Control of Cell Growth and Differentiation 98 Part II - Immunologic Basis of Hematology 114 Chapter 7 - Overview of the Immune System (Including Compartmentalization of the Immune Response) 114 Chapter 8 - B-Cell Development 121 Chapter 9 - T-Cell Immunity 136 Chapter 10 - Regulation of Activation of B and T Lymphocytes 145 Chapter 11 - Tolerance and Autoimmunity 159 Part III - Biology of Stem Cells and Disorders of Hematopoiesis 172 Chapter 12 - Stem Cell Model of Hematopoiesis 172 Chapter 13 - Anatomy and Physiology of Hematopoiesis 185 Chapter 14 - Growth Factors, Cytokines, and the Control of Hematopoiesis 205 Chapter 15 - Biology of Erythropoiesis, Erythroid Differentiation, and Maturation 267 Chapter 16 - Granulopoiesis and Monocytopoiesis 290 Chapter 17 - Thrombocytopoiesis 326 Chapter 18 - Inherited Forms of Bone Marrow Failure 344 Chapter 19 - Aplastic Anemia 383 Chapter 20 - Paroxysmal Nocturnal Hemoglobinuria 425 Chapter 21 - Pure Red Cell Aplasia 440 Part IV - Red Blood Cells 461 Chapter 22 - Pathobiology of the Human Erythrocyte and Its Hemoglobins 461 Chapter 23 - Approach to the Adult and Child with Anemia 474 Chapter 24 - Anemia of Chronic Diseases 489 Chapter 25 - Erythrocytosis 499 Chapter 26 - Disorders of Iron Metabolism: Iron Deficiency and Overload 514 Chapter 27 - Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias 544 Chapter 28 - Megaloblastic Anemias 573 Chapter 29 - Thalassemia Syndromes 622 Chapter 30 - Sickle Cell Disease 651 Chapter 31 - Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias 706 Chapter 32 - Red Cell Enzymopathies 715 Chapter 33 - Red Cell Membrane Disorders 735 Chapter 34 - Autoimmune Hemolytic Anemias 774 Chapter 35 - Extrinsic Nonimmune Hemolytic Anemias 802 Part V - Host Defense and Its Disorders 820 Chapter 36 - Immunoglobulins: Polyclonal and Monoclonal Antibodies 820 Chapter 37 - Complement Biology 832 Chapter 38 - Normal Neutrophil Structure and Function 854 Chapter 39 - Monocyte and Macrophage Development and Function 889 Chapter 40 - Eosinophilia, Eosinophil-Associated Diseases, and the Hypereosinophilic Syndrome 911 Chapter 41 - Disorders of Phagocyte Function and Number 940 Chapter 42 - Disorders of Lymphocyte Function 989 Chapter 43 - Histiocytic Disorders 1018 Chapter 44 - Lysosomal Storage Diseases: Perspective and Principles 1041 Chapter 45 - Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases 1062 Chapter 46 - The Spleen and Its Disorders 1078 Chapter 47 - Basophils, Mast Cells, and Systemic Mastocytosis 1092 Part VI - Hematologic Malignancies 1118 Chapter 48 - Cytogenetics and Neoplasia 1118 Chapter 49 - The Molecular Basis of Neoplasia 1150 Chapter 50 - Pharmacology and Molecular Mechanism of Action or Resistance of Antineoplastic Agents: Current Status and Future Potential 1171 Chapter 51 - Clinical Application of Cytokines and Biologic Response Modifiers 1234 Chapter 52 - Pathobiology of Acute Myeloid Leukemia 1281 Chapter 53 - Clinical Manifestations of Acute Myeloid Leukemia 1306 Chapter 54 - Therapy for Acute Myeloid Leukemia 1339 Chapter 55 - Acute Myeloid Leukemia in Children 1367 Chapter 56 - Pathobiology of Acute Lymphoblastic Leukemia 1392 Chapter 57 - Clinical Manifestations of Acute Lymphoblastic Leukemia 1419 Chapter 58 - Treatment of Childhood Acute Lymphoblastic Leukemia 1433 Chapter 59 - Acute Lymphocytic Leukemia in Adults 1450 Chapter 60 - Myelodysplastic Syndrome 1475 Chapter 61 - Polycythemia Vera 1502 Chapter 62 - Chronic Myelogenous Leukemia 1533 Chapter 63 - Agnogenic Myeloid Metaplasia 1562 Chapter 64 - Primary Thrombocythemia 1587 Chapter 65 - Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children 1613 Chapter 66 - Pathobiology of Non-Hodgkin Lymphomas 1626 Chapter 67 - Pathology and Histogenesis of Hodgkin Disease 1651 Chapter 68 - Hodgkin Disease: Clinical Manifestations, Staging, and Therapy 1669 Chapter 69 - The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas 1694 Chapter 70 - Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma 1723 Chapter 71 - Malignant Lymphomas in Childhood 1778 Chapter 72 - Chronic Lymphocytic Leukemia 1797 Chapter 73 - Hairy Cell Leukemia 1821 Chapter 74 - Cutaneous T-Cell Lymphomas 1837 Chapter 75 - AIDS-Related Lymphomas 1857 Chapter 76 - Multiple Myeloma and Other Plasma Cell Disorders 1875 Chapter 77 - Amyloidosis 1895 Chapter 78 - Atypical Immune Lymphoproliferations 1915 Chapter 79 - Clinical Approaches to Infections in the Compromised Host 1934 Chapter 80 - Nutritional Support of Patients with Hematologic Malignancies 1990 Chapter 81 - Psychosocial Aspects of Hematologic Disorders 2010 Chapter 82 - Pain Management and Antiemetic Therapy in Hematologic Disorders 2021 Chapter 83 - Indwelling Access Devices 2041 Part VII - Transplantation Chapter 84 - Overview of Stem Cell Transplantation 2058 Chapter 85 - Hematopoietic Stem Cell Transplantation for Nonmalignant Diseases 2066 Chapter 86 - Results of Allogeneic Stem Cell Transplantation for Malignant Disorders 2093 Chapter 87 - Results of Autologous Stem Cell Transplantation for Hematologic Malignancies 2112 Chapter 88 - Clinical Results of Autologous Stem Cell Transplantation for Solid Tumors in Adults 2130 Chapter 89 - Unrelated Donor Stem Cell Transplantation Therapy 2149 Chapter 90 - Placental and Umbilical Cord Blood Transplantation 2159 Chapter 91 - Preparative Regimens for Stem Cell Transplantation 2180 Chapter 92 - Practical Aspects of Stem Cell Collection 2199 Chapter 93 - Graft-versus-Host Disease and Graft-versus-Leukemia Effect 2223 Chapter 94 - Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease, and Provide a Graft-versus-Tumor Effect 2245 Chapter 95 - Gene Therapy for Hematologic Disorders 2276 Chapter 96 - Experimental Cell Therapy 2287 Chapter 97 - Complications After Stem Cell Transplantation 2304 Part VIII - Hemostasis and Thrombosis Chapter 98 - Megakaryocyte and Platelet Structure 2324 Chapter 99 - The Molecular Basis for Platelet Function 2332 Chapter 100 - The Molecular Basis for Platelet Activation 2348 Chapter 101 - The Blood Vessel Wall 2369 Chapter 102 - Molecular Basis of Blood Coagulation 2387 Chapter 103 - Molecular and Cellular Basis of Fibrinolysis 2408 Chapter 104 - Regulatory Mechanisms in Hemostasis: Natural Anticoagulants 2425 Chapter 105 - Clinical Evaluation of Hemorrhagic Disorders: The Bleeding History and Differential Diagnosis of Purpura 2446 Chapter 106 - Laboratory Evaluation of Hemostatic Disorders 2468 Chapter 107 - Structure, Biology, and Genetics of Factor VIII 2479 Chapter 108 - Biochemistry of Factor IX and Molecular Biology of Hemophilia B 2506 Chapter 109 - Clinical Aspects and Therapy of Hemophilia 2525 Chapter 110 - Inhibitors in Hemophilia 2553 Chapter 111 - Other Clotting Factor Deficiencies 2563 Chapter 112 - Quantitative and Qualitative Disorders of Fibrinogen 2584 Chapter 113 - Structure, Biology, and Genetics of von Willebrand Factor 2600 Chapter 114 - Clinical Aspects of and Therapy for von Willebrand Disease 2611 Chapter 115 - Vitamin K: Metabolism and Disorders 2629 Chapter 116 - Inhibitors of Blood Coagulation 2638 Chapter 117 - Disseminated Intravascular Coagulation 2667 Chapter 118 - Hemostatic Defects Associated with Dysproteinemias 2688 Chapter 119 - Disorders of Coagulation and Platelets in the Neonate 2697 Chapter 120 - Hypercoagulable States 2712 Chapter 121 - Oral Anticoagulant Therapy 2749 Chapter 122 - Heparin 2765 Chapter 123 - Thrombolytic Therapy 2782 Chapter 124 - Venous Thromboembolism 2805 Chapter 125 - Arterial Thromboembolism 2825 Chapter 126 - Immune Throbocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura 2837 Chapter 127 - Thrombocytopenia Due to Decreased Platelet Production 2868 Chapter 128 - Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome 2882 Chapter 129 - Thrombocytopenia Due to Platelet Destruction and Hypersplenism 2900 Chapter 130 - Hereditary Disorders of Platelet Function 2922 Chapter 131 - Acquired Disorders of Platelet Function 2948 Part IX - Transfusion Medicine 2966 Chapter 132 - Human Blood Group Antigens and Antibodies 2966 Chapter 133 - Human Platelet Antigens 2994 Chapter 134 - HLA and Neutrophil Antigen and Antibody Systems 3012 Chapter 135 - Principles of Red Blood Cell Transfusion 3045 Chapter 136 - Principles of Platelet Transfusion Therapy 3056 Chapter 137 - Principles of Neutrophil (Granulocyte) Transfusions 3071 Chapter 138 - Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins 3081 Chapter 139 - Preparation of Plasma-Derived and Recombinant Human Plasma Proteins 3099 Chapter 140 - Transfusion Principles for Congenital Coagulation Disorders 3114 Chapter 141 - Hemapheresis and Cellular Therapy 3126 Chapter 142 - Transfusion Reactions 3139 Chapter 143 - Transfusion-Transmitted Diseases 3155 Chapter 144 - Autologous Blood Transfusion 3172 Chapter 145 - Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation 3182 Chapter 146 - Red Cell Substitutes 3202 Part X - Consultative Hematology 3211 Chapter 147 - Hematologic Complications of Liver Disease and Alcoholism 3211 Chapter 148 - Hematologic Complications of Renal Disease 3225 Chapter 149 - Hematologic Aspects of Pregnancy 3246 Chapter 150 - Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis 3263 Chapter 151 - Hematologic Manifestations of Childhood Illness 3278 Chapter 152 - Hematologic Problems in Patients with Cancer and Chronic Inflammatory Disorders 3305 Chapter 153 - Hematologic Manifestations of Infectious Disease 3318 Chapter 154 - Hematologic Manifestations of HIV Infection 3331 Part XI - Special Tests and Procedures 3366 Chapter 155 - Bone Marrow Aspiration and Morphology 3366 Chapter 156 - Automated Analysis of Blood Cells 3378 Chapter 157 - Laboratory Detection of Hemoglobinopathies and Thalassemias 3393 Chapter 158 - Antenatal Diagnosis of Hematologic Disorders 3407 Chapter 159 - Electrophoretic and Immunochemical Analysis of Human Immunoglobulins 3428 Chapter 160 - Use of Molecular Techniques in the Analysis of Hematologic Diseases 3439