Mass Spectrometry : A Textbook

This highly successful textbook, acclaimed for its comprehensiveness, accuracy, and its many excellent illustrations and photographs now comes in its second edition. Completely revised and substantially extended it offers: – New chapter on **Tandem Mass Spectrometry** covering instrumentation, methods for ion activation (CID, ECD, ETD, IRMPD), and applications – New chapter on **Ambient Mass Spectrometry** (DART, DESI, and more) – New chapter on **Inorganic Mass Spectrometry** including element speciation and imaging – **Learning Objectives** for all chapters – **Advanced Instrumentation** such as orbitraps, linear ion traps, tandem TOFs, FT-ICR and the highly variable hybrid instruments – Updated **Problems and Solutions website** (www.ms-textbook.com) **__Jürgen H. Gross__** provides in-depth explanations of concepts, methods, and techniques. Students and professionals alike are guided step-by-step from the basics to the successful application of mass spectrometry. Starting from the very principles of gas-phase ion chemistry, isotopic composition, and accurate mass, **__Jürgen H. Gross__** leads through the design of all types of mass analyzers and ionization methods to mass spectral interpretation and coupling techniques. His book offers a balanced mixture of practice-oriented information and theoretical background supported by a wealth of references. From reviews of the previous edition: “...one of the best textbooks on mass spectrometry I have seen so far.” __International Journal of Mass Spectrometry__ “...can be recommended unreservedly as a textbook and reference source...” __Angewandte Chemie, International Edition__ This book is tailored for students and professionals as well as novices from other fields to mass spectrometry. It will guide them from the basics to the successful application of mass spectrometry in their daily research. Starting from the very principles of gas-phase ion chemistry and isotopic properties, it leads through the design of mass analyzers and ionization methods in use to mass spectral interpretation and coupling techniques. Step by step the readers will learn how mass spectrometry works and what it can do as a powerful tool in their hands. The book comprises a balanced mixture of practice-oriented information and theoretical background. The clear layout, a wealth of high-quality figures and a database of exercises and solutions, accessible via the publisher's web site, support teaching and learning Front Matter....Pages i-xxiv Introduction....Pages 1-20 Principles of Ionization and Ion Dissociation....Pages 21-66 Isotopic Composition and Accurate Mass....Pages 67-116 Instrumentation....Pages 117-221 Practical Aspects of Electron Ionization....Pages 223-248 Fragmentation of Organic Ions and Interpretation of EI Mass Spectra....Pages 249-350 Chemical Ionization....Pages 351-380 Field Ionization and Field Desorption....Pages 381-413 Tandem Mass Spectrometry....Pages 415-478 Fast Atom Bombardment....Pages 479-506 Matrix-Assisted Laser Desorption/Ionization....Pages 507-559 Electrospray Ionization....Pages 561-620 Ambient Mass Spectrometry....Pages 621-649 Hyphenated Methods....Pages 651-684 Inorganic Mass Spectrometry....Pages 685-716 Back Matter....Pages 717-753 This book offers a balanced mixture of practice-oriented information and theoretical background as well as numerous references, clear illustrations, and useful data tables. Problems and solutions are accessible via a special website. This new edition has been completely revised and extended; it now includes three new chapters on tandem mass spectrometry, interfaces for sampling at atmospheric pressure, and inorganic mass spectrometry. This edition discusses tandem mass spectrometry, interfaces for sampling at atmospheric pressure, and inorganic mass spectrometry. Starting from the very principles of gas-phase ion chemistry and isotopic properties, it leads through the design of mass analyzers and ionization methods in use to mass spectral interpretation and coupling techniques