Nitric Oxide

Nitric oxide (NO) has been discovered to play a fundamental role in a number of biological phenomena. This book describes various aspects of nitric oxide biology, physiology and pharmacology. It is divided into three sections. The first part deals with the basic chemistry and enzymology of NO, thus laying a molecular basis for what follows. The middle part surveys the physiological roles of NO under normal conditions. The concluding part explores the relevance of NO to disease, both as a pathogenic factor and a therapeutic target. The book thus provides detailed information on NO biology to the reader unfamiliar with the field and represents a reference work for scientists working in an NO-related field of biomedical research. Each chapter, written by experts in their fields, gives a broad introduction followed by a comprehensive review of the current knowledge and a detailed reference list. Front Matter....Pages I-XXIX Introduction....Pages 1-3 Front Matter....Pages 5-5 The Chemical Biology of Nitric Oxide. Balancing Nitric Oxide with Oxidative and Nitrosative Stress....Pages 7-29 Front Matter....Pages 31-31 Enzymology of Nitric Oxide Synthases....Pages 33-70 Regulation of Nitric Oxide Synthase Expression and Activity....Pages 71-91 Enzymology of Soluble Guanylyl Cyclase....Pages 93-109 Nitric Oxide Synthase Inhibitors I: Substrate Analogs and Heme Ligands....Pages 111-135 Nitric-Oxide-Synthase Inhibitors II — Pterin Antagonists/Anti-Pterins....Pages 137-158 Mechanisms of Cellular Resistance Against Nitric Oxide....Pages 159-175 Front Matter....Pages 177-177 Nitric Oxide and Regulation of Vascular Tone....Pages 179-206 Regulation of Cardiac Function by Nitric Oxide....Pages 207-234 Regulation of Platelet Function....Pages 235-257 The Physiological Roles of Nitric Oxide in the Central Nervous System....Pages 259-275 The Role of Nitric Oxide in the Peripheral Nervous System....Pages 277-313 Nitric Oxide and Neuroendocrine Function....Pages 315-328 The Role of Nitric Oxide in Kidney Function....Pages 329-361 Front Matter....Pages 363-363 Therapeutic Importance of Nitrovasodilators....Pages 365-384 Therapeutic Potential of NOS Inhibitors in Septic Shock....Pages 385-397 Inhalation Therapy with Nitric Oxide Gas....Pages 399-441 The Function of Nitric Oxide in the Immune System....Pages 443-492 Nitric Oxide: A True Inflammatory Mediator....Pages 493-523 Front Matter....Pages 363-363 Nitric Oxide in the Immunopathogenesis of Type 1 Diabetes....Pages 525-544 The Role of Nitric Oxide in Cardiac Ischaemia-Reperfusion....Pages 545-570 Nitric Oxide and Atherosclerosis....Pages 571-617 Nitric Oxide in Brain Ischemia/Reperfusion Injury....Pages 619-637 Therapeutic Potential of Nitric Oxide Synthase Gene Manipulation....Pages 639-653 Back Matter....Pages 655-667