Stem Cell-Based Tissue Repair

Content: PART I: Stem cells sources for practical regenerative medicine; Clinical applications of stem cells; Embryonic and adult HSC; Adult non-hematopoietic stem cells: characterization, isolation; Screening Approaches for the Characterization of Stem Cells for regenerative medicine; Part II: TISSUE REGENERATION and STEM CELL ENGINEERING; MSC as vector for cancer therapies; Promises limitations in adult cell based tissue regeneration; Re-programming stem cells and induced adult stem cells; Culturing non-hematopoietic stem cells and requirements of GMP in stem cell based therapies; Stem cells as vectors of genes; PART III: ORGAN TRAGETTED TISSUE REPAIR WITH STEM CELLS; Regeneration of bone; Regeneration of cartilage; Stem cells based replacement tissue for muscle and heart repair; Regeneration of the vasculature; Regeneration of the pancreas/islets and liver; Treating neurodegenerative tissue with embryonic stem cells; Regeneration of the genitourinary system; Strategies to adjust immunomodulation by adult stem cells; Engineering of stem cell homing and labelling of stem cells

The need for customized stem cell therapies for specific conditions will be a major issue in the coming decades. This unique book by experts in the field reviews the subject as it stands today. Its coverage includes: basic and applied stem cell research and history; sources of adult stem cells; a comparison of difficulties in derivation, and the applications of embryonic and adult stem cells. Specific topics dealt with include: -advantages and problems associated with stem cell / matrix interactions -stem cell differentiation -difficulties using stem cells for clinical application -stem cell based tissue engineering - myth or reality -stem cells and immunity -natural biological matrices versus synthetic - biocompatibility and integration -stem cell delivery, labeling, imaging and tracking -bioreactors: 2D and 3D cell culturing for in-vitro studies and for stem cell implantation -ethical and safety issues -Good Manufacturing Practice (GMP).

The need for customized stem cell therapies for specific conditions will be a major issue in the coming decades. This unique book by experts in the field reviews the subject as it stands today. Its coverage includes: basic and applied stem cell research and history; sources of adult stem cells; a comparison of difficulties in derivation, and the applications of embryonic and adult stem cells. Specific topics dealt with include advantages and problems associated with stem cell / matrix interactions and stem cell differentiation, difficulties using stem cells for clinical application, stem cell based tissue engineering - myth or reality, stem cells and immunity, natural biological matrices versus synthetic (biocompatibility and integration), stem cell delivery, labeling, imaging and tracking, bioreactors: 2D and 3D cell culturing for in-vitro studies and for stem cell implantation, ethical and safety issues and Good Manufacturing Practice (GMP). 9781849730013......Page 1 i_iv......Page 2 v_vi......Page 6 vii_xii......Page 8 001_021......Page 14 022_044......Page 35 045_080......Page 58 081_088......Page 94 089_116......Page 102 117_140......Page 130 141_158......Page 154 159_177......Page 172 178_202......Page 191 203_234......Page 216 235_247......Page 248 248_272......Page 261 273_295......Page 286 296_307......Page 309 308_323......Page 321 324_345......Page 337 346_365......Page 359 366_377......Page 379 378_392......Page 391 This unique book by leading experts reviews the key therapeutic issues related to stem cell technology.