Tuberculosis

The gratifYing response to the first edition of Tuberculosis has prompted this revision. There are many important changes incorporated into this edition, including the dramatic effect of AIDS on the incidence and clinical mani­ festations of mycobacterial infection, new developments in epidemiology and bacteriology, and thoroughly updated therapeutic recommendations and principles of prophylaxis. The chapters that deal with clinical manifestations of tuberculosis have also been updated and include important and clinically applicable information on manifestations of tuberculosis in both the normal and immunocomprom­ ised host. As with the first edition, it is hoped that this text will continue to represent a definitive resource for both the basic scientist and the clinician who deal with the prevention and treatment of mycobacterial infection. II Preface to the First Edition We have just witnessed the lOOth anniversary of Koch's discovery of the tubercle bacillus. This event did not end the centuries-long saga of tuber­ culosis, however; it was but one major step in the ongoing struggle to un­ derstand and combat this disease. Tuberculosis is very much with us today, and its clinical manifestations and principles of treatment must be understood by both the primary care physician and the specialist. This monograph covers all aspects of tuberculosis in a single volume. It is divided into three parts, covering, respectively, general considerations, clin­ ical manifestations, and atypical mycobacterial infection. Front Matter....Pages i-xviii Epidemiology and Host Factors....Pages 1-15 Pathogenesis and Immunology: Basic Aspects....Pages 17-39 Pathophysiology and Immunology: Clinical Aspects....Pages 41-50 Bacteriology and Bacteriologic Diagnosis of Tuberculosis....Pages 51-61 Tuberculin Skin Testing....Pages 63-68 Chemotherapy of Tuberculosis....Pages 69-88 Prophylaxis....Pages 89-94 Pulmonary Tuberculosis....Pages 95-106 Upper Respiratory Tract Tuberculosis....Pages 107-113 Otologic Tuberculosis....Pages 115-117 Ocular Tuberculosis....Pages 119-128 Central Nervous System Tuberculosis....Pages 129-142 Tuberculous Lymphadenitis....Pages 143-153 Genitourinary Tuberculosis....Pages 155-163 Bone and Joint Tuberculosis....Pages 165-178 Cardiovascular Tuberculosis....Pages 179-187 Mycobacterial Enteritis....Pages 189-192 Tuberculous Peritonitis....Pages 193-197 Tuberculosis of the Liver and Biliary Tract....Pages 199-224 Cutaneous Tuberculosis....Pages 225-232 Miliary Tuberculosis....Pages 233-245 Endocrine and Metabolic Aspects of Tuberculosis....Pages 247-256 Hematologic Changes in Tuberculosis....Pages 257-263 Human Immunodeficiency Virus and Mycobacterial Infections....Pages 265-275 Perinatal Tuberculosis....Pages 277-279 Clinical Syndromes and Diagnosis of Nontuberculous (“Atypical”) Mycobacterial Infection....Pages 281-293 Treatment of Diseases Caused by Nontuberculous Mycobacteria....Pages 295-302 Back Matter....Pages 303-323 This now classic text covers all aspects of mycobacterial infection. For the Third Edition, all previous chapters featured in the highly acclaimed first and second editions have been thoroughly rewritten and four new chapters have been added - on AIDS, perinatal infection, immunopathogenesis, and hematologic complications. The latest concepts of pathophysiology, clinical presentation, and therapy all covered in a practical, clinical, user-friendly format, including recent data on multiply-resistant TB. This updated edition is an indispensable tool for all clinicians and scientists who treat and study tuberculosis. The recent resurgence of tuberculosis on a worldwide epidemic state necessitates the inclusion of this new edition in the libraries of all physicians.

Appropriate for: Infectious Disease Specialists, Pulmonary Scientists.

This study of all aspects of mycobacterial infection has been revised to include new chapters on research into tuberculosis and AIDS. The latest concepts of immunopathogens are presented in a clinical format, along with the most recent data on new strains of multiply-resistant TB.